Publications
Selected papers (click on icons above for full list)
2023
Sirtuin 6 activation rescues the age-related decline in DNA damage repair in primary human chondrocytes. Copp ME, Shine J, Brown HL, Nimmala KR, Hansen OB, Chubinskaya S, Collins JA, Loeser RF, Diekman BO. Aging (Albany NY). 2023 Dec 9:15. doi: 10.18632/aging.205394.
Use of a novel magnetically actuated compression system to study the temporal dynamics of axial and lateral strain in human osteochondral plugs. Rich MJ, Burnash S, Krishnan RR, Chubinskaya S, Loeser, RF, Diekman BO. Journal of Biomechanics. 2023. doi: 10.1016/j.jbiomech.2023.111887.
Aging and the emerging role of cellular senescence in osteoarthritis. Osteoarthritis Cartilage. 2023 Dec 2:S1063-4584(23)00997-4. doi: 10.1016/j.joca.2023.11.018.
Epigenetics as a mediator of genetic risk in osteoarthritis: role during development, homeostasis, aging, and disease progression. Richard D, Capellini TD, Diekman BO. Am J Physiol Cell Physiol. 2023 May 1;324(5):C10178-C1088. PMC10191130.
2022
3D chromatin structure in chondrocytes identifies putative osteoarthritis risk genes. Thulson E, Davis ES, D’Costa S, Coryell PR, Kramer NE, Mohlke KL, Loeser RF, Diekman BO#, Phanstiel DH#. Genetics. 2022 Nov 30;222(4):iyac141. 13698. PMC9713432, doi: 10.1093/genetics/iyac141. #co-corresponding authors.
Comet assay for quantification of the increased DNA damage burden in primary human chondrocytes with aging and osteoarthritis. Copp ME, Chubinskaya S, Bracey DN, Shine J, Sessions G, Loeser RF, Diekman BO. Aging Cell. 2022 Sep;21(9):e13698. PMC9470893, doi: 10.1111/acel.13698.
2021
Mechanisms and therapeutic implications of cellular senescence in osteoarthritis. Coryell PR, Diekman BO, Loeser RF. Nat Rev Rheumatol. 2021 Jan;17(1):47-57. PMC8035495.
Sirtuin 6 (SIRT6) regulates redox homeostasis and signaling events in human articular chondrocytes. Collins JA, Kapustina M, Bolduc JA, Pike JFW, Diekman BO, Mix K, Chubinskaya S, Eroglu E, Michel T, Poole LB, Furdui CM, Loeser RF. Free Radic Biol Med. 2021 Apr;166:90-103. PMC8009856.
2020
The combination of mitogenic stimulation and DNA damage induces chondrocyte senescence. Copp ME, Flanders MC, Gagliardi R, Gilbertie JM, Sessions GA, Chubinskaya S, Loeser RF, Schnabel LV, Diekman BO#. Osteoarthritis Cartilage. 2020 Nov 20:S1063-4584(20)31172-9. PMC7925350, doi: 10.1016/j.joca.2020.11.004. #corresponding author
Arp2/3 inactivation causes intervertebral disc and cartilage degeneration with dysregulated TonEBP-mediated osmoadaptation. Tessier S, Doolittle AC, Sao K, Rotty JD, Bear JE, Ulici V, Loeser RF, Shapiro IM, Diekman BO#, Risbud MV#. Journal of Clinical Investigation Insight. Epub Jan 21, 2020. PMC7101139, doi: 10.1172/jci.insight.131382. #corresponding authors.
Dynamic interplay between connective tissues and the surrounding environment during aging. Diekman, BO. Connective Tissue Research. 2020 Jan;61(1):1-3. PMC in process, PMID 31782325, doi: 10.1080/03008207.2020.1682282.
Deletion of JNK Enhances Senescence in Joint Tissues and Increases the Severity of Age-Related Osteoarthritis in Mice. Loeser RF, Kelley KL, Armstrong A, Collins JA, Diekman BO, Carlson CS. Arthritis Rheumatol. 2020 Oct;72(10):1679-1688. PMC7669715.
Microfluidics for the study of mechanotransduction. Griffith CM, Huang SA, Cho C, Khare TM, Rich M, Lee GH, Ligler FS, Diekman BO, Polacheck WJ. J Phys D Appl Phys. 2020 May 27;53(22):224004. PMC8034607.
2019
Engineered cartilage from human chondrocytes with homozygous knockout of cell cycle inhibitor p21. D’Costa S, Rich MJ, Diekman BO. Tissue Engineering Part A. 2019 Nov 22. PMC in process, PMID 31642391, doi: 10.1089/ten.TEA.2019.0214.
Controlled induction and targeted elimination of p16INK4a-expressing chondrocytes in cartilage explant culture. Sessions GA, Copp ME, Liu JY, Sinkler MA, D’Costa S, Diekman BO. FASEB J. 2019 Nov;33(11):12364-12373. PMC6988852, PMID 31408372, doi: 10.1096/fj.201900815RR.
p16INK4a deletion in cells of the intervertebral disc affects their matrix homeostasis and senescence associated secretory phenotype without altering onset of senescence. Novais EJ, Diekman BO, Shapiro IM, Risbud MV. Matrix Biology. 2019 Feb 24. PMC6708504.
Cells exhibiting strong p16INK4a promoter activation in vivo display features of senescence. Liu JY, Souroullas GP, Diekman BO, Krishnamurthy J, Hall BM, Sorrentino JA, Parker JS, Sessions GA, Gudkov AV, Sharpless NE. Proc Natl Acad Sci. 2019 Feb 12. PMC6377452.
2018
Expression of p16INK4a is a biomarker of chondrocyte aging but does not cause osteoarthritis. Diekman BO, Collins JA, Sessions GA, Strum S, Knecht A, Mitin N, Carlson C, Loeser RF, Sharpless NE. Aging Cell. 2018 Aug;17(4):e12771. PMC6052464, doi: 10.1111/acel.12771.
Does joint injury make young joints old? Diekman BO, Collins JA, Loeser RF. J Am Acad Orthop Surg Epub Aug 21, 2018. PMC6203621, doi: 10.5435/JAAOS-D-18-00394.
Targeting aging for disease modification in osteoarthritis. Collins JA*, Diekman BO*, Loeser RF. Curr Opin Rheum. 2018 Jan;30(1): 101-107. PMC5886778. *co-first authors
2016
Aging and the pathogenesis of osteoarthritis. Loeser RF#, Collins JA, Diekman BO. Nature Reviews Rheumatology. 2016 Jul;12(7):412-420. PMC4938009. #corresponding author
Before 2016 (Work done in lab of Farsh Guilak at Duke)
Knockdown of the cell cycle inhibitor p21 enhances cartilage formation by induced pluripotent stem cells. Diekman BO*, Thakore PI*, O’Connor SK, Willard VP, Brunger JM, Christoforou N, Leong K, Gersbach CA, Guilak F. Tissue Engineering Part A. 2015 Apr;21(7-8): 1261-74. PMC4394871. *co-first authors.
Use of cartilage derived from mouse induced pluripotent stem cells for osteoarthritis drug screening. Willard VP*, Diekman BO*, Sanchez-Adams J, Christoforou N, Leong KW, Guilak F. Arthritis & Rheumatology. 2014 Nov;66(11):3062-72. PMC4308724. *co-first authors.
Intra-articular delivery of purified mesenchymal stem cells from C57BL/6 or MRL/MpJ superhealer mice prevents post-traumatic arthritis. Diekman BO, Wu CL, Louer CR, Furman BD, Huebner JL, Kraus VB, Olson SA, Guilak F. Cell Transplantation. 2013;22(8):1395-408. PMC3891895.
Stem cell-based therapies for osteoarthritis: Challenges and opportunities. Diekman BO and Guilak F. Current Opinion in Rheumatology. 2013 Jan;25(1):119-26. PMC3616879.
Cartilage tissue engineering using differentiated and purified induced pluripotent stem cells. Diekman BO, Christoforou N, Willard VP, Sun H, Sanchez-Adams J, Leong KW, Guilak F. Proceedings of the National Academy of Sciences USA. 2012 Nov 20;109(47):19172-7. PMC3511083.
The effects of BMP6 overexpression on adipose stem cell chondrogenesis: Interactions with dexamethasone and exogenous growth factors. Diekman BO*, Estes BT*, Guilak F. Journal of Biomedical Materials Research Part A. 2010 Jun 1;93(3):994-1003. PMC3616877. *co-first authors.
Chondrogenesis of adult stem cells from adipose tissue and bone marrow: Induction by growth factors and cartilage derived matrix. Diekman BO, Rowland CR, Caplan AI, Lennon D, Guilak F. Tissue Engineering Part A. 2010 Feb;16(2):523-33. PMC2813149.
Diet-induced obesity alters the differentiation potential of stem cells isolated from bone marrow, adipose tissue, and infrapatellar fat pad: The effects of free fatty acids. Wu CL, Diekman BO, Jain D, Guilak F. International Journal of Obesity. 2013 Aug;37(8):1079-87. PMC3582830.
Nicolas Andry award: multipotent adult stem cells from adipose tissue for musculoskeletal tissue engineering. Monolayer cell expansion conditions affect the chondrogenic potential of adipose-derived stem cells. Guilak F, Estes BT, Diekman BO, Moutos FT, Gimble JM. 2010 Clinical Orthopaedics and Related Research. 2010 Sep;468(9):2530-40. PMC2919887
Hypoxia, RONS and energy metabolism in articular cartilage. Fermor B#, Gurumurthy A, Diekman BO. Osteoarthritis and Cartilage. 2010 Sep;18(9):1167-73. PMC2929267. #corresponding author.
Isolation of adipose-derived stem cells and their induction to a chondrogenic phenotype. Estes BT, Diekman BO, Gimble JM, Guilak F. Nature Protocols. 2010 Jul;5(7):1294-311. PMC3219531.
In vitro generation of mechanically functional cartilage grafts based on adult human stem cells and 3D-woven poly(varepsilon-caprolactone) scaffolds. Valonen PK, Moutos FT, Kusanagi A, Moretti MG, Diekman BO, Welter JF, Caplan AI, Guilak F, Freed LE. Biomaterials. 2010 Mar; 31(8):2193-200. PMC2824534.
Monolayer cell expansion conditions affect the chondrogenic potential of adipose-derived stem cells. Estes BT, Diekman BO, Guilak F. Biotechnology and Bioengineering. 2008 Mar 1;99(4):986-95. PMC3576028.